As a migraine sufferer, I have long used Excedrin. I knew the products were the same and was amazed when I crossed paths with someone who didn't know. At the stores where I shop, the prices have been the same no matter what the box. The advantage of different boxes for Excedrin may be more shelf space for their product. The real savings is just buying a generic store brand with the exact same ingredients. Generic versions have remained on the shelves during this time when the Excedrin brand was gone.